Tuesday, July 24, 2007

What is cancer of the paranasal sinus and nasal cavity?

Cancer of the paranasal sinus and nasal cavity is a disease in which cancer (malignant) cells are found in the tissues of the paranasal sinuses or nasal cavity. The paranasal sinuses are small hollow spaces around the nose. The sinuses are lined with cells that make mucus, which keeps the nose from drying out; the sinuses are also a space through which the voice can echo to make sounds when a person talks or sings. The nasal cavity is the passageway just behind the nose through which air passes on the way to the throat during breathing. The area inside the nose is called the nasal vestibule.
There are several paranasal sinuses, including the frontal sinuses above the nose, the maxillary sinuses in the upper part of either side of the upper jawbone, the ethmoid sinuses just behind either side of the upper nose, and the sphenoid sinus behind the ethmoid sinus in the center of the skull. Cancer of the paranasal sinus and nasal cavity most commonly starts in the cells that line the oropharynx. Much less often, cancer of the paranasal sinus and nasal cavity starts in the color-making cells called melanocytes, and is called a melanoma. If the cancer starts in the muscle or connecting tissue, it is called a sarcoma. Another type of cancer that can occur here, but grows more slowly, is called an inverting papilloma. Cancers called midline granulomas may also occur in the paranasal sinuses or nasal cavity, and they cause the tissue around them to break down.
A doctor should be seen for any of the following problems:
* Blocked sinuses that do not clear.
* A sinus infection.* Nosebleeds.
* A lump or sore that doesn’t heal inside the nose.
* Frequent headaches or sinus pain.
* Swelling or other trouble with the eyes.
* Pain in the upper teeth.
* Dentures that no longer fit well.
If there are symptoms, a doctor will examine the nose using a mirror and lights. The doctor may order a CT scan (a special x-ray that uses a computer) or an MRI scan (an x-ray-like procedure that uses magnetic energy) to make a picture of the inside of parts of the body. A special instrument (called a rhinoscope or a nasoscope) may be put into the nose to see inside. If tissue that is not normal is found, the doctor will need to cut out a small piece and look at it under the microscope to see if there are any cancer cells. This is called a biopsy.
Sometimes the doctor will need to cut into the sinus to do a biopsy. The chance of recovery (prognosis) depends on where the cancer is in the sinuses, whether the cancer is just in the area where it started or has spread to other tissues (the stage), and the patient’s general state of health.

What is Cancer?

The name for diseases in which the body's cells become abnormal and divide without control. Cancer cells may invade nearby tissues. And they may spread through the bloodstream and lymphatic system to other parts of the body.

How is Cancer formed?

Cancer cells are formed from normal cells due to a modification / mutation of DNA and/or RNA. These modifications / mutations can occur spontaneously (II Law of Thermodynamics - increase of entropy) or they may be induced by other factors such as: nuclear radiation, electromagnetic radiation (microwaves, X-rays, Gamma-rays, Ultraviolet-rays, etc.), viruses, bacteria and fungi, parasites (due to tissue inflamation/irritation), heat, chemicals in the air, water and food, mechanical cell-level injury, free radicals, evolution and ageing of DNA and RNA, etc. All these can produce mutations that may start cancer. Cancer can be called therefore "Entropic Disease" since it is associated with the increase of entropy of the organism to the point where the organism cannot correct this itself.
External intervention is required to allow the organism to return to an stable entropic state.Cancer cells are formed continuously in the organism (it is estimated that there are about 10,000 cancer cells at any given time in a healthy person). The question is why some of these result in macroscopic-level cancers and some don't. First, not all damaged cells can multiply and many of them die quickly. Those which have the potential to divide and form cancer are effectively destroyed by the various mechanisms available to the immune system.
This process takes place continuously. Therefore cancer develops if the immune system is not working properly and/or the amount of cells produced is too great for the immune system to eliminate.
The rate of DNA and RNA mutations can be too high under some conditions such as: unhealthy environment (due to radiation, chemicals, etc.), poor diet (unhealthy cell environment), people with genetic predispositions to mutations and people of advanced age (above 80).